A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark

Pharmacognosy Research,2022,14,4,442-445.DOI:10.5530/pres.14.4.64Published:October 2022Type:Original ArticleAuthors:Jean Pierre Abdou, Jean Noël Nyemb, Momeni, Atikou Fadimatou, Abel Joël Yaya Gbaweng, Paul Tsopmejio, Guidawa Fawa, and Muhammad I. Choudhary Author(s) affiliations:Jean Abdou1,2, Nyemb3,*, Momeni1, Fadimatou1, Gbaweng1, Tsopmejio4, Fawa5, Choudhary6 1Department of Chemistry, Faculty Science, University Ngaoundere, Ngaoundere 454, CAMEROON. 2Centre for Research on Medicinal Plants Traditional Medicine, Institute Medical Studies, Yaounde, 3Department Refining Petrochemistry, National Advanced School Mines Petroleum Industries, Maroua, Kaele, 4Department Organic Yaounde 1, 5Department Biological 6H. E. J. International Center Chemical Sciences (ICCBS), Karachi, PAKISTAN. Abstract:Background: Dalbergia boehmii (Leguminosae), is a medicinal plant used in the Northen part Cameroon, against digestive tract diseases fever. Objectives: This work which search bioactive molecules through natural products, aimed to isolate, characterize evaluate cytotoxicity compounds from D. boehmii. Materials Methods: investigations were carrying out stem barks using chromatographic techniques. Structures elucidation isolated done 1D 2D NMR as well EI-MS literature data. Some evaluated vitro MCF-7 cell lines their activity, MTT colorimetric method. Results: The chemical investigation leaded isolation new ceramide derivative named Dalbergiamide (1), triterpene identified olean-12-ene-3,11-dione (2) here first time genus, along with two known compounds, glucoside 3-O-β- D-sitosterol (3) 3-O-β-D-stigmasterol (4). Compounds 1 2 found be cytotoxic at 50 μM IC50 value 17.13 35.52 ± 2.95 respectively. Conclusion: These promising results suggested more in-depth studies should carried this order assess its potential fight cancer Keywords:cytotoxicity, boehmii, MCF-7, Natural ProductsView:PDF (460.2 KB)